Angiotensin II receptor antagonists : current perspectives by Mancia Giuseppe

By Mancia Giuseppe

Because angiotensin II is likely one of the such a lot powerful vasoconstrictors and a massive stimulus for the secretion of aldosterone from the adrenal gland, the improvement of of angiotensin II inhibitors is a vital step in regulating blood strain. This type of drug is well-tolerated by means of pateints and those medicinal drugs have the further virtue over ACE inhibitors in that they're now not linked to cough. simply because so much medications could be given as soon as day-by-day and, like ACEIs, they've got an invaluable additive hypotensive impact together with diuretics, they seem to be a welcome healing software within the remedy of high blood pressure. This moment version builds at the good fortune of the 1st and brings to the reader all of the most modern advancements, medical trial facts, and the contributors's own views whilst treating sufferers with angiotensin II receptors antagonists.

  • offers chapters by means of recognized members within the fields of either high blood pressure and middle failure, specifically in regards to pharmacological interventions
  • covers the hot function of AIIR in neuroprotection
  • builds upon the strengths of the 1st edition
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    J Hypertens 2003; 21(Suppl 2):543–6. 40. Unger T, McInnes GT, Neutel JM, Böhm M. The role of olmesartan medoxomil in the management of hypertension. Drugs 2004; 64:2731–9 41. Benson SC, Pershadsingh HA, Ho CI et al. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPAR-␥ modulating activity. Hypertension 2004; 43:993–1002. 42. Schupp M, Janke J, Clasen R, Unger T, Kintscher U. Angiotensin type I receptor blockers include peroxisome proliferator-activated receptor-␥ activity.

    J Cardiovasc Pharmacol 1995; 26:354–62. 20. Zhang J. Pharmacological effects of angiotensin II and non-peptidergic receptor antagonists. PhD Thesis (ISBN 90-9008377-4), University of Amsterdam, 1995; 145. 21. Zhang J, Pfaffendorf M, Zhang JS, van Zwieten PA. A non-competitive type of angiotensin IIreceptor antagonism by losartan in renal artery preparations. Eur J Pharmacol 1994; 252:337–40. 22. Baan H, Chang PC, Vermeij P, Pfaffendorf M, van Zwieten PA. Effects of losartan on vasoconstrictor responses to angiotensin II in the human forearm vascular bed of healthy volunteers.

    Points represent the mean (n ϭ 5–6,SEM shown by vertical bars) of the increase in force expressed ad a percentage of the initial maximal responses to AII. Note the depression of the maximal effect of AII in the presence of losartan, thus indicating insurmountable antagonism. 21 Profiles of individual AT1 receptor antagonists Losartan Losartan was the first AT1 receptor antagonist developed clinically and then applied on a large-scale in antihypertensive treatment. Its safety and efficacy appear to be beyond doubt.

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