Novartis Foundation Symposium 216 - Alcohol and by Novartis Foundation

By Novartis Foundation

Either well timed and topical, this publication examines an important features of the connection among alcohol intake and well-being. Drawing jointly a lot new and fascinating paintings during this region, it studies this emotive topic from a dispassionate point of view. it's going to offer a company base for additional examine into the results of alcohol at the cardiovascular procedure, and into public well-being attitudes to what's either a common excitement and challenge.

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Hyperuricaemia 7. Disturbances of cortisol and androgen metabolism 8. Enhanced fibrogenesis overemphasized. Thus pre-treatment of rats with methylene blue, which dissipates the increased NADH/NAD ratio, does not prevent hepatic lipid accumulation when these rats are then fed alcohol (Ryle et a1 1985, Ryle 1986). Similarly, direct measurement of human hepatic fatty acid synthesis in vitro shows no effect of ethanol on synthesis rates: tissue from alcoholics show base line rates of fatty acid synthesis below that of normal tissue with no change on the addition of ethanol (Venkatesan et a1 1986, Simpson et a1 1994).

That has been looked at very carefully and these are all the fluffy-puffy triglycerides. They do not metabolize to the small VLDL which is thought to be atherogenic. The third area is the resins, which actually raise HDL slightly but raise triglycerides more. These again are thought to be the fluffy-puffy kind. Also the evidence so far is that the triglycerides which are raised by high carbohydrate diets are thought to be fluffy-puffy triglycerides. Marmot: How solid are the data that the fluffy triglycerides are not associated with the risk of atherosclerosis?

We have been surprised by the low pick-up of enterovirus infection in the presence of a history of significant alcohol intake. I rather thought it would be the other way round: that these patients would have had altered immunity and thus less defence against viral infection. Some patients are clearly predisposed to the deleterious effects of alcohol, having had a previous viral infection. All the patients with dilated cardiomyopathy who drink in excess of 60g alcohol/day may depress their ventricular function.

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